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OCR: dren and GH deficiency causes short stature in ch occurs sometimes retards bone development. I et (for most often as an isolated congenital defe ssociation example, isolated GHRH deficiency), in amour, or with a craniopharyngioma or pituitary t fective after brain irradiation for malignancy. E Hor treatment with parenteral biosynthetic C tential for GHRH is now available, although the p comes catch-up growth decreases as the child be al. At birth, older. Early diagnosis is therefore essent ire can, these children look normal. Growth fail one and however, usually be recognised between ed much three years of age, but may only be detec